Open Access Articles- Top Results for Hypocretin (orexin) receptor 2

Hypocretin (orexin) receptor 2

SymbolsHCRTR2 ; OX2R
External IDsOMIM602393 MGI2680765 HomoloGene1168 IUPHAR: 322 ChEMBL: 4792 GeneCards: HCRTR2 Gene
RNA expression pattern
File:PBB GE HCRTR2 207393 at tn.png
More reference expression data
RefSeq (mRNA)NM_001526NM_198962
RefSeq (protein)NP_001517NP_945200
Location (UCSC)Chr 6:
55.11 – 55.28 Mb
Chr 9:
76.23 – 76.32 Mb
PubMed search[1][2]
Orexin receptor type 2
Symbol Orexin_rec2
Pfam PF03827
InterPro IPR004060

Orexin receptor type 2 (Ox2R or OX2), also known as hypocretin receptor type 2, is a protein that in humans is encoded by the HCRTR2 gene.[1]


OX2 is a G-protein coupled receptor expressed exclusively in the brain. It has 64% identity with OX1. OX2 binds both orexin A and orexin B neuropeptides. OX2 is involved in the central feedback mechanism that regulates feeding behaviour.[1]




See also


  1. ^ a b "Entrez Gene: HCRTR2 hypocretin (orexin) receptor 2". 
  2. ^ McAtee LC, Sutton SW, Rudolph DA, Li X, Aluisio LE, Phuong VK, Dvorak CA, Lovenberg TW, Carruthers NI, Jones TK (August 2004). "Novel substituted 4-phenyl-[1,3]dioxanes: potent and selective orexin receptor 2 (OX(2)R) antagonists". Bioorg. Med. Chem. Lett. 14 (16): 4225–9. PMID 15261275. doi:10.1016/j.bmcl.2004.06.032. 
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  5. ^ Roecker AJ, Mercer SP, Schreier JD et al. (February 2014). "Discovery of 5-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia". ChemMedChem 9 (2): 311–22. PMID 24376006. doi:10.1002/cmdc.201300447. 
  6. ^  Missing or empty |title= (help)
  7. ^ Cole AG, Stroke IL, Qin LY, Hussain Z, Simhadri S, Brescia MR, Waksmunski FS, Strohl B, Tellew JE, Williams JP, Saunders J, Appell KC, Henderson I, Webb ML (October 2008). "Synthesis of (3,4-dimethoxyphenoxy)alkylamino acetamides as orexin-2 receptor antagonists". Bioorg. Med. Chem. Lett. 18 (20): 5420–3. PMID 18815029. doi:10.1016/j.bmcl.2008.09.038. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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