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Open Access Articles- Top Results for IDH3G

IDH3G

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsIDH3G ; H-IDHG
External IDsOMIM300089 MGI1099463 HomoloGene55803 GeneCards: IDH3G Gene
EC number1.1.1.41
RNA expression pattern
File:PBB GE IDH3G 202471 s at tn.png
File:PBB GE IDH3G 214333 x at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez342115929
EnsemblENSG00000067829ENSMUSG00000002010
UniProtP51553P70404
RefSeq (mRNA)NM_004135NM_008323
RefSeq (protein)NP_004126NP_032349
Location (UCSC)Chr HG1497_PATCH:
152.95 – 152.96 Mb
Chr X:
73.78 – 73.79 Mb
PubMed search[1][2]

Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial is an enzyme that in humans is encoded by the IDH3G gene.[1][2]

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the gamma subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. This gene is a candidate gene for periventricular heterotopia. Several alternatively spliced transcript variants of this gene have been described, but only some of their full length natures have been determined.[2]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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  1. ^ The interactive pathway map can be edited at WikiPathways: "TCACycle_WP78". 

References

  1. ^ Brenner V, Nyakatura G, Rosenthal A, Platzer M (Nov 1997). "Genomic organization of two novel genes on human Xq28: compact head to head arrangement of IDH gamma and TRAP delta is conserved in rat and mouse". Genomics 44 (1): 8–14. PMID 9286695. doi:10.1006/geno.1997.4822. 
  2. ^ a b "Entrez Gene: IDH3G isocitrate dehydrogenase 3 (NAD+) gamma". 

Further reading

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