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Open Access Articles- Top Results for IKZF2

IKZF2

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Identifiers
SymbolsIKZF2 ; ANF1A2; HELIOS; ZNF1A2; ZNFN1A2
External IDsOMIM606234 MGI1342541 HomoloGene22659 GeneCards: IKZF2 Gene
RNA expression pattern
File:PBB GE IKZF2 220567 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2280722779
EnsemblENSG00000030419ENSMUSG00000025997
UniProtQ9UKS7P81183
RefSeq (mRNA)NM_001079526NM_011770
RefSeq (protein)NP_001072994NP_035900
Location (UCSC)Chr 2:
213.86 – 214.02 Mb
Chr 1:
69.53 – 69.69 Mb
PubMed search[1][2]

Zinc finger protein Helios is a protein that in humans is encoded by the IKZF2 gene.[1][2][3]

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined.[3]

References

  1. ^ Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale ST (Apr 1998). "Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin". Genes Dev 12 (6): 782–96. PMC 316626. PMID 9512513. doi:10.1101/gad.12.6.782. 
  2. ^ Kelley CM, Ikeda T, Koipally J, Avitahl N, Wu L, Georgopoulos K, Morgan BA (Aug 1998). "Helios, a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors". Curr Biol 8 (9): 508–15. PMID 9560339. doi:10.1016/S0960-9822(98)70202-7. 
  3. ^ a b "Entrez Gene: IKZF2 IKAROS family zinc finger 2 (Helios)". 

Further reading

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External links


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