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IKZF3

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Identifiers
SymbolsIKZF3 ; AIO; AIOLOS; ZNFN1A3
External IDsOMIM606221 MGI1342542 HomoloGene8269 GeneCards: IKZF3 Gene
RNA expression pattern
File:PBB GE IKZF3 221092 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2280622780
EnsemblENSG00000161405ENSMUSG00000018168
UniProtQ9UKT9O08900
RefSeq (mRNA)NM_001257408NM_011771
RefSeq (protein)NP_001244337NP_035901
Location (UCSC)Chr 17:
37.92 – 38.02 Mb
Chr 11:
98.46 – 98.55 Mb
PubMed search[1][2]

Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[1][2][3]

Function

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[3]

Interactions

IKZF3 has been shown to interact with BCL2-like 1[4] and HRAS.[5]

References

  1. ^ Morgan B, Sun L, Avitahl N, Andrikopoulos K, Ikeda T, Gonzales E, Wu P, Neben S, Georgopoulos K (Jun 1997). "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". EMBO J 16 (8): 2004–13. PMC 1169803. PMID 9155026. doi:10.1093/emboj/16.8.2004. 
  2. ^ Hosokawa Y, Maeda Y, Takahashi E, Suzuki M, Seto M (Feb 2000). "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics 61 (3): 326–9. PMID 10552935. doi:10.1006/geno.1999.5949. 
  3. ^ a b "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)". 
  4. ^ Rebollo A, Ayllón V, Fleischer A, Martínez CA, Zaballos A (December 2001). "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". J. Immunol. 167 (11): 6366–73. PMID 11714801. doi:10.4049/jimmunol.167.11.6366. 
  5. ^ Romero F, Martínez-A C, Camonis J, Rebollo A (June 1999). "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". EMBO J. 18 (12): 3419–30. PMC 1171421. PMID 10369681. doi:10.1093/emboj/18.12.3419. 

Further reading

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External links

Template:Gene-17-stub This article incorporates text from the United States National Library of Medicine, which is in the public domain.