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Open Access Articles- Top Results for IL2RA

IL2RA

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Identifiers
SymbolsIL2RA ; CD25; IDDM10; IL2R; TCGFR
External IDsOMIM147730 MGI96549 HomoloGene360 IUPHAR: 1695 ChEMBL: 1778 GeneCards: IL2RA Gene
RNA expression pattern
File:PBB GE IL2RA 211269 s at tn.png
File:PBB GE IL2RA 206341 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez355916184
EnsemblENSG00000134460ENSMUSG00000026770
UniProtP01589P01590
RefSeq (mRNA)NM_000417NM_008367
RefSeq (protein)NP_000408NP_032393
Location (UCSC)Chr 10:
6.05 – 6.1 Mb
Chr 2:
11.64 – 11.69 Mb
PubMed search[1][2]

Interleukin-2 receptor alpha chain is a protein that in humans is encoded by the IL2RA gene.[1]

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is currently unknown.[2]

Infection by the protozoan Trypanosoma cruzi causes Chagas disease, characterized by a reduction in the amount of IL2RA expressed on the surface of immune cells. This leads to chronic immune suppression, becoming increasingly severe over the course of many years and ultimately resulting in death if left untreated.


References

  1. ^ Leonard WJ, Donlon TA, Lebo RV, Greene WC (Aug 1985). "Localization of the gene encoding the human interleukin-2 receptor on chromosome 10". Science 228 (4707): 1547–9. PMID 3925551. doi:10.1126/science.3925551. 
  2. ^ "Entrez Gene: IL2RA interleukin 2 receptor, alpha". 

Further reading

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