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IRF3

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Identifiers
SymbolIRF3
External IDsOMIM603734 MGI1859179 HomoloGene1208 GeneCards: IRF3 Gene
RNA expression pattern
File:PBB GE IRF3 202621 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez366154131
EnsemblENSG00000126456ENSMUSG00000003184
UniProtQ14653P70671
RefSeq (mRNA)NM_001197122NM_016849
RefSeq (protein)NP_001184051NP_058545
Location (UCSC)Chr 19:
50.16 – 50.17 Mb
Chr 7:
45 – 45 Mb
PubMed search[1][2]

Interferon regulatory factor 3, also known as IRF3, is an interferon regulatory factor.[1]

Function

IRF3 is a member of the interferon regulatory transcription factor (IRF) family.[1] IRF3 was originally discovered as a homolog of IRF1 and IRF2. IRF3 has been further characterized and shown to contain several functional domains including a nuclear export signal, a DNA-binding domain, a C-terminal IRF association domain and several regulatory phosphorylation sites.[2] IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP.[3] This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes.[4]

IRF3 plays an important role in the innate immune system's response to viral infection.[5] Aggregated MAVS have been found to activate IRF3 dimerization.[6]

File:Toll-like receptor pathways revised.jpg
Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations


Interactions

IRF3 has been shown to interact with IRF7.[7]

References

  1. ^ a b Hiscott J, Pitha P, Genin P, Nguyen H, Heylbroeck C, Mamane Y et al. (1999). "Triggering the interferon response: the role of IRF-3 transcription factor". J. Interferon Cytokine Res. 19 (1): 1–13. PMID 10048763. doi:10.1089/107999099314360. 
  2. ^ Lin R, Heylbroeck C, Genin P, Pitha PM, Hiscott J (Feb 1999). "Essential Role of Interferon Regulatory Factor 3 in Direct Activation of RANTES Chemokine Transcription". Mol Cell Biol 19 (2): 959–66. PMC 116027. PMID 9891032. 
  3. ^ Yoneyama M, Suhara W, Fujita T (2002). "Control of IRF-3 activation by phosphorylation". J. Interferon Cytokine Res. 22 (1): 73–6. PMID 11846977. doi:10.1089/107999002753452674. 
  4. ^ "Entrez Gene: IRF3 interferon regulatory factor 3". 
  5. ^ Collins SE, Noyce RS, Mossman KL (Feb 2004). "Innate Cellular Response to Virus Particle Entry Requires IRF3 but Not Virus Replication". J Virol 78 (4): 1706–17. PMC 369475. PMID 14747536. doi:10.1128/JVI.78.4.1706-1717.2004. 
  6. ^ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS Forms Functional Prion-Like Aggregates To Activate and Propagate Antiviral Innate Immune Response". Cell 146 (3): 448–61. PMC 3179916. PMID 21782231. doi:10.1016/j.cell.2011.06.041. 
  7. ^ Au WC, Yeow WS, Pitha PM (Feb 2001). "Analysis of functional domains of interferon regulatory factor 7 and its association with IRF-3". Virology 280 (2): 273–82. PMID 11162841. doi:10.1006/viro.2000.0782. 

Further reading

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External links

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