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IRF5

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsIRF5 ; SLEB10
External IDsOMIM607218 MGI1350924 HomoloGene8088 GeneCards: IRF5 Gene
RNA expression pattern
File:PBB GE IRF5 205469 s at tn.png
File:PBB GE IRF5 205468 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez366327056
EnsemblENSG00000128604ENSMUSG00000029771
UniProtQ13568P56477
RefSeq (mRNA)NM_001098627NM_001252382
RefSeq (protein)NP_001092097NP_001239311
Location (UCSC)Chr 7:
128.58 – 128.59 Mb
Chr 6:
29.53 – 29.54 Mb
PubMed search[1][2]

Interferon regulatory factor 5 is a protein that in humans is encoded by the IRF5 gene.[1]

Function

IRF5 is a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative splice variants encoding different isoforms exist.[1]

Clinical significance

IRF5 acts as a molecular switch that controls whether macrophages will promote or inhibit inflammation. Blocking the production of IRF5 in macrophages may help treat a wide range of autoimmune diseases, and that boosting IRF5 levels might help treat people whose immune systems are weak, compromised, or damaged. IRF5 seems to work "either by interacting with DNA directly, or by interacting with other proteins that themselves control which genes are switched on."[2]

See also

References

  1. ^ a b "Entrez Gene: IRF5 interferon regulatory factor 5". 
  2. ^ Krausgruber T, Blazek K, Smallie T, Alzabin S, Lockstone H, Sahgal N, Hussell T, Feldmann M, Udalova IA (January 2011). "IRF5 promotes inflammatory macrophage polarization and T(H)1-T(H)17 responses". Nat Immunol 12 (3): 231–238. PMID 21240265. doi:10.1038/ni.1990. Lay summaryMedScape. 


Further reading

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External links

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