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IRX3

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Identifiers
SymbolsIRX3 ; IRX-1; IRXB1
External IDsOMIM612985 MGI1197522 HomoloGene7385 GeneCards: IRX3 Gene
Orthologs
SpeciesHumanMouse
Entrez7919116373
EnsemblENSG00000177508ENSMUSG00000031734
UniProtP78415P81067
RefSeq (mRNA)NM_024336NM_001253822
RefSeq (protein)NP_077312NP_001240751
Location (UCSC)Chr 16:
54.32 – 54.32 Mb
Chr 8:
91.8 – 91.8 Mb
PubMed search[1][2]

Iroquois-class homeodomain protein IRX-3, also known as Iroquois homeobox protein 3, is a protein that in humans is encoded by the IRX3 gene.[1]

Function

IRX3 is a member of the Iroquois homeobox gene family and plays a role in an early step of neural development.[2] Members of this family appear to play multiple roles during pattern formation of vertebrate embryos.[1][3]

Clinical significance

Association with obesity

Obesity-associated noncoding sequences within FTO interact with the promoter of IRX3 and FTO in human, mouse, and zebrafish. Obesity-associated single nucleotide polymorphisms are related to the expression of IRX3 (not FTO) in the human brain. A direct connection between the expression of IRX3 and body mass and composition was shown through the decrease in body weight of 25-30% in IRX3-deficient mice. This suggests that IRX3 influences obesity.[4]

References

  1. 1.0 1.1 "Entrez Gene: iroquois homeobox 3". 
  2. Bellefroid EJ, Kobbe A, Gruss P, Pieler T, Gurdon JB, Papalopulu N (January 1998). "Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification". EMBO J. 17 (1): 191–203. PMC 1170370. PMID 9427753. doi:10.1093/emboj/17.1.191. 
  3. Lewis MT, Ross S, Strickland PA, Snyder CJ, Daniel CW (June 1999). "Regulated expression patterns of IRX-2, an Iroquois-class homeobox gene, in the human breast". Cell Tissue Res. 296 (3): 549–54. PMID 10370142. doi:10.1007/s004410051316. 
  4. Smemo S, Tena JJ, Kim KH, Gamazon ER, Sakabe NJ, Gómez-Marín C, Aneas I, Credidio FL, Sobreira DR, Wasserman NF, Lee JH, Puviindran V, Tam D, Shen M, Son JE, Vakili NA, Sung HK, Naranjo S, Acemel RD, Manzanares M, Nagy A, Cox NJ, Hui CC, Gomez-Skarmeta JL, Nóbrega MA (12 March 2014). "Obesity-associated variants within FTO form long-range functional connections with IRX3". Nature 507 (7492): 371–375. PMID 24646999. doi:10.1038/nature13138. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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