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Open Access Articles- Top Results for ITPR3

ITPR3

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Identifiers
SymbolsITPR3 ; IP3R; IP3R3
External IDsOMIM147267 MGI96624 HomoloGene1675 IUPHAR: 745 ChEMBL: 3904 GeneCards: ITPR3 Gene
Orthologs
SpeciesHumanMouse
Entrez371016440
EnsemblENSG00000096433ENSMUSG00000042644
UniProtQ14573P70227
RefSeq (mRNA)NM_002224NM_080553
RefSeq (protein)NP_002215NP_542120
Location (UCSC)Chr 6:
33.59 – 33.66 Mb
Chr 17:
27.06 – 27.12 Mb
PubMed search[1][2]

Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene.[1] The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.[2]

Function

ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.[3]

See also

References

  1. ^ "Entrez Gene: inositol 1". 
  2. ^ Yamamoto-Hino M, Sugiyama T, Hikichi K et al. (1994). "Cloning and characterization of human type 2 and type 3 inositol 1,4,5-trisphosphate receptors". Recept. Channels 2 (1): 9–22. PMID 8081734. 
  3. ^ Chaudhari N, Roper SD (August 2010). "The cell biology of taste". J. Cell Biol. 190 (3): 285–96. PMC 2922655. PMID 20696704. doi:10.1083/jcb.201003144. 

Further reading

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External links


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