Open Access Articles- Top Results for Ibopamine


Systematic (IUPAC) name
5-[2-(methylamino)ethyl]-2-[(2-methylpropanoyl)oxy]phenyl 2-methylpropanoate
Clinical data
AHFS/ International Drug Names
66195-31-1 7pxY
C01CA16 S01FB03
PubChem CID 68555
ChemSpider 61829 7pxN
UNII 8ZCA2I2L11 7pxY
KEGG D04488 7pxY
Chemical data
Formula C17H25NO4
307.385 g/mol
 14pxN (what is this?)  (verify)

Ibopamine is a sympathomimetic drug, designed as a prodrug of epinine, used in ophthalmology.[1] It induces mydriasis.[2] It also has been investigated for use in the treatment of congestive heart failure.[3]

It acts on D1[4][5] and α receptors as an agonist.[6]

Ibopamine was first prepared by Casagrande and co-workers.[7]

See also


  1. ^ Magacho L, Costa ML, Dessimoni A, de Avila MP (2006). "Comparison between the 1% and 2% ibopamine provocative test in primary open-angle glaucoma patients: sensitivity, specificity and tolerability". Arq Bras Oftalmol 69 (5): 695–9. PMID 17187138. doi:10.1590/S0004-27492006000500015. 
  2. ^ Marchini G, Babighian S, Tosi R, Perfetti S, Bonomi L (June 2001). "Effects of 2% ibopamine on pupil, refraction, anterior segment anatomy and intraocular pressure". J Ocul Pharmacol Ther 17 (3): 215–23. PMID 11436942. doi:10.1089/108076801750295254. 
  3. ^ van Veldhuisen DJ, Man in 't Veld AJ, Dunselman PH et al. (November 1993). "Double-blind placebo-controlled study of ibopamine and digoxin in patients with mild to moderate heart failure: results of the Dutch Ibopamine Multicenter Trial (DIMT)". J. Am. Coll. Cardiol. 22 (6): 1564–73. PMID 7901256. doi:10.1016/0735-1097(93)90579-P. 
  4. ^ Metra M, Missale C, Spano PF, Cas LD (May 1995). "Dopaminergic drugs in congestive heart failure: hemodynamic and neuroendocrine responses to ibopamine, dopamine, and dihydroergotoxine". J. Cardiovasc. Pharmacol. 25 (5): 732–40. PMID 7630152. doi:10.1097/00005344-199505000-00008. 
  5. ^ Lieverse AG, Girbes AR, Van Veldhuisen DJ et al. (July 1995). "The effects of ibopamine on glomerular filtration rate and plasma norepinephrine remain preserved during prolonged treatment in patients with congestive heart failure". Eur. Heart J. 16 (7): 937–42. PMID 7498209. 
  6. ^ "IngentaConnect Ibopamine Stimulates -Adrenergic Receptors and D1 Dopaminergic Re...". 
  7. ^ C. Casagrande, F. Santangelo, C. Saini, F. Doggi, F. Gerli and O. Cerri (1986). "Synthesis and chemical properties of ibopamine and of related esters of N-substituted dopamines-synthesis of ibopamine metabolites." Arzneimittelforschung 36 291-303.

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