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Open Access Articles- Top Results for Ifenprodil

Ifenprodil

Ifenprodil
200px
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This page is a soft redirect. Names

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IUPAC name
4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
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ATC code C04AX28
ChEMBL ChEMBL305187 7pxN
ChemSpider 3561 7pxY
Jmol-3D images Image
KEGG D08064 7pxY
PubChem Template:Chembox PubChem/format
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This page is a soft redirect. Properties

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C21H27NO2
Molar mass 325.445
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

Ifenprodil is a selective inhibitor of the NMDA receptor.[1] Its effect is specific to receptors composed of the NR1 (glycine-binding NMDA receptor subunit 1; GluN1) and NR2B (glutamate-binding NMDA receptor subunit 2; GluN2B) subunits.[2]

NMDA receptors are multimeric ionotropic glutamate receptors composed of four subunits. NR1 is obligate for functional expression. Other subunits include NR2A, NR2B, and the more recently discovered NR3 subunits. Ifenprodil selectively blocks NMDA receptors containing the NR2B subunit.

References

  1. ^ Reynolds IJ, Miller RJ (1989). "Ifenprodil is a novel type of N-methyl-D-aspartate receptor antagonist: interaction with polyamines". Mol. Pharmacol. 36 (5): 758–65. PMID 2555674. 
  2. ^ Korinek M, Kapras V, Vyklicky V, Adamusova E, Borovska J, Vales K, Stuchlik A, Horak M, Chodounska H, Vyklicky L Jr (Dec 2011). "Neurosteroid modulation of N-methyl-d-aspartate receptors: Molecular mechanism and behavioral effects". Steroids 76 (13): 1409–18. PMID 21925193. doi:10.1016/j.steroids.2011.09.002. 

Template:Glutamate receptor ligands


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