Open Access Articles- Top Results for Ifoxetine


Systematic (IUPAC) name
Clinical data
  • Uncontrolled
PubChem CID 71971
ChemSpider 64977
UNII LHH887104B 7pxY
Chemical data
Formula C13H19NO2
221.30 g/mol

Ifoxetine (CGP-15,210-G) is a selective serotonin reuptake inhibitor (SSRI) which was investigated as an antidepressant in the 1980s but was never marketed.[1][2][3] Ifoxetine selectively blocks the reuptake of serotonin in the brain supposedly without affecting it in the periphery.[3] Supporting this claim, ifoxetine was found to be efficacious in clinical trials and was very well tolerated, producing almost no physical side effects or other complaints of significant concern.[3]


  1. Burrows GD, McIntyre IM, Judd FK, Norman TR (August 1988). "Clinical effects of serotonin reuptake inhibitors in the treatment of depressive illness". The Journal of Clinical Psychiatry. 49 Suppl: 18–22. PMID 3045107. 
  2. Waldmeier PC, Maître L, Baumann PA et al. (October 1986). "Ifoxetine, a compound with atypical effects on serotonin uptake". European Journal of Pharmacology 130 (1-2): 1–10. PMID 2877890. doi:10.1016/0014-2999(86)90177-9. 
  3. 3.0 3.1 3.2 Delini-Stula A, Fischbach R, Gauthier JM et al. (July 1987). "First clinical experience with ifoxetine, a new 5-HT reuptake blocker with particular emphasis on the side-effect profile of the 5-HT-uptake inhibiting drugs". International Clinical Psychopharmacology 2 (3): 201–15. PMID 3320185. doi:10.1097/00004850-198707000-00003. 

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