Adverts

Open Access Articles- Top Results for Inosine monophosphate synthase

Inosine monophosphate synthase

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsATIC ; AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
External IDsOMIM601731 MGI1351352 HomoloGene2983 ChEMBL: 2518 GeneCards: ATIC Gene
EC number2.1.2.3, 3.5.4.10
RNA expression pattern
File:PBB GE ATIC 208758 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez471108147
EnsemblENSG00000138363ENSMUSG00000026192
UniProtP31939Q9CWJ9
RefSeq (mRNA)NM_004044NM_026195
RefSeq (protein)NP_004035NP_080471
Location (UCSC)Chr 2:
216.18 – 216.21 Mb
Chr 1:
71.56 – 71.58 Mb
PubMed search[1][2]

Bifunctional purine biosynthesis protein PURH is a protein that in humans is encoded by the ATIC gene.[1][2][3]

ATIC encodes an enzyme which generates inosine monophosphate from aminoimidazole carboxamide ribonucleotide.

It has two functions:

  • EC 2.1.2.3 - 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase
  • EC 3.5.4.10 - IMP cyclohydrolase

References

  1. Rayl EA, Moroson BA, Beardsley GP (Mar 1996). "The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping". J Biol Chem 271 (4): 2225–33. PMID 8567683. doi:10.1074/jbc.271.4.2225. 
  2. Sugita T, Aya H, Ueno M, Ishizuka T, Kawashima K (Nov 1997). "Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase". J Biochem 122 (2): 309–13. PMID 9378707. doi:10.1093/oxfordjournals.jbchem.a021754. 
  3. "Entrez Gene: ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase". 

Further reading

</dl>

External links

Template:Nucleotide metabolism



Lua error in package.lua at line 80: module 'Module:Buffer' not found.