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Interferon regulatory factors

Interferon regulatory factor transcription factor
File:PDB 1irf EBI.jpg
interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
Identifiers
Symbol IRF
Pfam PF00605
InterPro IPR001346
SCOP 1if1
SUPERFAMILY 1if1

Interferon regulatory factors are proteins which regulate transcription of interferons (see regulation of gene expression).[1]

They are used in the JAK-STAT signaling pathway.[2]

Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes.[3] The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.[3]

Genes

See also

References

  1. ^ Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie 89 (6–7): 744–53. PMC 2139905. PMID 17399883. doi:10.1016/j.biochi.2007.01.014. 
  2. ^ Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010. 
  3. ^ a b Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054. 

External links


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