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Interferon regulatory factors

Interferon regulatory factor transcription factor
File:PDB 1irf EBI.jpg
interferon regulatory factor-2 dna binding domain, nmr, minimized average structure
Symbol IRF
Pfam PF00605
InterPro IPR001346
SCOP 1if1

Interferon regulatory factors are proteins which regulate transcription of interferons (see regulation of gene expression).[1]

They are used in the JAK-STAT signaling pathway.[2]

Interferon regulatory factors contain a conserved N-terminal region of about 120 amino acids, which folds into a structure that binds specifically to the interferon consensus sequence (ICS), which is located upstream of the interferon genes.[3] The remaining parts of the interferon regulatory factor sequence vary depending on the precise function of the protein.[3]


See also


  1. ^ Paun A, Pitha PM (2007). "The IRF family, revisited". Biochimie 89 (6–7): 744–53. PMC 2139905. PMID 17399883. doi:10.1016/j.biochi.2007.01.014. 
  2. ^ Tsuneya Ikezu; Howard E. Gendelman (2008). Neuroimmune Pharmacology. Springer. pp. 213–. ISBN 978-0-387-72572-7. Retrieved 28 November 2010. 
  3. ^ a b Weisz A, Marx P, Sharf R, Appella E, Driggers PH, Ozato K, Levi BZ (December 1992). "Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes". J. Biol. Chem. 267 (35): 25589–96. PMID 1460054. 

External links

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