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Open Access Articles- Top Results for Interleukin-6 receptor

Interleukin-6 receptor

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Identifiers
SymbolsIL6R ; CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80
External IDsOMIM147880 MGI105304 HomoloGene474 IUPHAR: 1708 GeneCards: IL6R Gene
RNA expression pattern
File:PBB GE IL6R 205945 at tn.png
File:PBB GE IL6R 217489 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez357016194
EnsemblENSG00000160712ENSMUSG00000027947
UniProtP08887P22272
RefSeq (mRNA)NM_000565NM_010559
RefSeq (protein)NP_000556NP_034689
Location (UCSC)Chr 1:
154.38 – 154.44 Mb
Chr 3:
89.87 – 89.91 Mb
PubMed search[1][2]

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Function

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytic cells IL6R gene expression may be regulated by MITF.[1]

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6[3] [4] [5] and Ciliary neurotrophic factor.[4][6]

See also

References

  1. ^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res 21 (6): 665–76. PMID 19067971. doi:10.1111/j.1755-148X.2008.00505.x. 
  2. ^ "Entrez Gene: IL6R interleukin 6 receptor". 
  3. ^ Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. 279 (1): 571–6. PMID 14557255. doi:10.1074/jbc.M311019200. 
  4. ^ a b Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J et al. (Mar 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528–35. PMID 12643274. doi:10.1074/jbc.M210044200. 
  5. ^ Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T et al. (Aug 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell 58 (3): 573–81. PMID 2788034. doi:10.1016/0092-8674(89)90438-8. 
  6. ^ Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. PMID 1281789. doi:10.1016/0014-5793(92)81489-9. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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