Open Access Articles- Top Results for Interleukin 10 receptor, alpha subunit

Interleukin 10 receptor, alpha subunit

SymbolsIL10RA ; CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
External IDsOMIM146933 MGI96538 HomoloGene1196 IUPHAR: 1727 GeneCards: IL10RA Gene
RNA expression pattern
File:PBB GE IL10RA 204912 at tn.png
More reference expression data
RefSeq (mRNA)NM_001558NM_008348
RefSeq (protein)NP_001549NP_032374
Location (UCSC)Chr 11:
117.86 – 117.87 Mb
Chr 9:
45.25 – 45.27 Mb
PubMed search[1][2]

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. IL10RA, is its human gene.

IL10RA has also recently been designated CDW210A (cluster of differentiation W210A).


The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases.[1]


Interleukin 10 receptor, alpha subunit has been shown to interact with:


  1. ^ "Entrez Gene: IL10RA interleukin 10 receptor, alpha". 
  2. ^ Ho AS, Liu Y, Khan TA, Hsu DH, Bazan JF, Moore KW (December 1993). "A receptor for interleukin 10 is related to interferon receptors". Proc. Natl. Acad. Sci. U.S.A. 90 (23): 11267–71. PMC 47963. PMID 8248239. doi:10.1073/pnas.90.23.11267. 
  3. ^ Josephson K, Logsdon NJ, Walter MR (July 2001). "Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site". Immunity 15 (1): 35–46. PMID 11485736. doi:10.1016/s1074-7613(01)00169-8. 
  4. ^ Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S et al. (May 1995). "Characterization of recombinant extracellular domain of human interleukin-10 receptor". J. Biol. Chem. 270 (21): 12906–11. PMID 7759550. doi:10.1074/jbc.270.21.12906. 
  5. ^ Josephson K, McPherson DT, Walter MR (December 2001). "Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 12): 1908–11. PMID 11717514. doi:10.1107/s0907444901016249. 
  6. ^ Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A (May 1999). "Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization". Eur. J. Biochem. 262 (1): 134–41. PMID 10231374. doi:10.1046/j.1432-1327.1999.00363.x. 
  7. ^ Usacheva A, Sandoval R, Domanski P, Kotenko SV, Nelms K, Goldsmith MA et al. (December 2002). "Contribution of the Box 1 and Box 2 motifs of cytokine receptors to Jak1 association and activation". J. Biol. Chem. 277 (50): 48220–6. PMID 12374810. doi:10.1074/jbc.M205757200. 
  8. ^ Usacheva A, Kotenko S, Witte MM, Colamonici OR (August 2002). "Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors". J. Immunol. 169 (3): 1302–8. PMID 12133952. doi:10.4049/jimmunol.169.3.1302. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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