|This biographical article needs additional citations for verification. (February 2013)|
July 16, 1926|
Brooklyn, New York
Fox Chase Cancer Center|
University of Pennsylvania
University of California, Irvine
|Alma mater||University of Chicago|
|Doctoral advisor||Template:If empty|
|Known for||Ubiquitin-mediated protein degradation|
|Notable awards||Nobel Prize in Chemistry (2004)|
|Spouse||Zelda Budenstein (4 children)|
Irwin A. Rose (born July 16, 1926) is an American biologist. Along with Aaron Ciechanover and Avram Hershko, he was awarded the 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation.
Rose was born in Brooklyn, New York into a secular Jewish family, the son of Ella (Greenwald) and Harry Royze, who owned a flooring store. Rose attended Washington State University for one year prior to serving in the Navy during World War II. Upon returning from the war he received his B.S. in 1948 and his Ph.D. in biochemistry in 1952, both from the University of Chicago. He served on the faculty of Yale School of Medicine's department of biochemistry from 1954 to 1963. He then joined Fox Chase Cancer Center's division of basic in 1963 and stayed there until he retired in 1995. He joined University of Pennsylvania during the 1970s and served as a Professor of Physical Biochemistry. He is currently a distinguished professor-in-residence in the Department of Physiology and Biophysics at the University of California, Irvine School of Medicine.
Irwin (Ernie) trained several postdoctoral fellows while at the Fox Chase Cancer Center in Philadelphia. These included Art Haas, the first to see Ubiquitin chains, Keith Wilkinson, the one to first identify APF-1 as Ubiquitin, and Cecile Pickart, a world class enzymologist in many parts of the Ub system.
- Hershko, A.; Ciechanover, A.; Rose, I.A. (1979), "Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP", Proc. Natl. Acad. Sci. USA 76 (7): 3107–3110, PMC 383772, PMID 290989, doi:10.1073/pnas.76.7.3107.
- Hershko, A.; Ciechanover, A.; Heller, H.; Haas, A.L.; Rose, I.A. (1980), "Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis", Proc. Natl. Acad. Sci. USA 77 (4): 1783–1786, PMC 348591, PMID 6990414, doi:10.1073/pnas.77.4.1783.
- Rose, Irwin (2005), "Early work on the ubiquitin proteasome system, an interview with Irwin Rose. Interview by CDD", Cell Death Differ. 12 (9): 1162–6, PMID 16094392, doi:10.1038/sj.cdd.4401700
- "Nobel Prize in Chemistry, 2004. Aaron Ciechanover, Avram Hershko and Irwin Rose", Indian J. Physiol. Pharmacol. 49 (1), 2005: 121, PMID 15881872
- Latonen, Leena; Laiho, Marikki (2004), "Nobel prize in chemistry goes to three persons with a key role in revealing the ubiquitin-mediated protein degradation pathway", Duodecim; lääketieteellinen aikakauskirja 120 (24): 2868–71, PMID 15700582
- Goldberg, Alfred L (2005), "Nobel committee tags ubiquitin for distinction", Neuron (Feb 3, 2005) 45 (3): 339–44, PMID 15694320, doi:10.1016/j.neuron.2005.01.019
- Neefjes, J; Groothuis, T A M; Dantuma, N P (2004), "The 2004 Nobel Prize in Chemistry for the discovery of ubiquitin-mediated protein degradation", Nederlands tijdschrift voor geneeskunde (Dec 25, 2004) 148 (52): 2579–82, PMID 15646859
- Vogel, Gretchen; Bachmair, A; Chau, V; Cohen, R; Coffino, P; Demartino, G; Deshaies, R; Dohmen, J et al. (2004), "Nobel Prizes. Gold medal from cellular trash", Science (Oct 15, 2004) 306 (5695): 400–1, PMID 15550643, doi:10.1126/science.306.5695.400b
- Giles, Jim (2004), "Chemistry Nobel for trio who revealed molecular death-tag", Nature (Oct 14, 2004) 431 (7010): 729, PMID 15483574, doi:10.1038/431729a
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