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Isoliquiritigenin

Isoliquiritigenin
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This page is a soft redirect. Names

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IUPAC name
(E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
Other names
6'-deoxychalcone
2',4,4'-Trihydroxychalcone
4,2',4'-Trihydroxychalcone
4'2'4'-trihydroxychalcone
2',4',4-Trihydroxychalcone
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961-29-5 7pxY
ChEBI CHEBI:310312 7pxN
ChEMBL ChEMBL129795 7pxN
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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C15H12O4
Molar mass 256.25 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Isoliquiritigenin is a licorice chalconoid, a type of natural phenols. It is under experimentation phase testing for use as a cancer treatment and as an aide for cocaine addiction. It is a sirtuin-activating compound.

Metabolism

The enzyme 6'-deoxychalcone synthase uses malonyl-CoA, 4-coumaroyl-CoA, NADPH, and H+ to produce CoA, isoliquiritigenin, CO2, NADP+, and H2O.

The enzyme isoliquiritigenin 2'-O-methyltransferase further transforms isoliquiritigenin into 2'-O-methylisoliquiritigenin.

Mechanism of action

Isoliquiritigenin has been found to potent (65 times higher affinity than diazepine) GABA-A benzodiapine receptor positive allosteric modulator.[1]

References

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