Adverts

Open Access Articles- Top Results for Isopregnanolone

Isopregnanolone

Isopregnanolone
200px
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Names

#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-

IUPAC name
(3β,5α)-3-Hydroxypregnan-20-one
Other names
Pregnanolone; sepranolone
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Identifiers#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-



516-55-2
ChemSpider 83761
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
colspan=2 style="background:#f8eaba; border-top:2px solid transparent; border-bottom:2px solid transparent; text-align:center;" #REDIRECTmw:Help:Magic words#Other
This page is a soft redirect. Properties

#REDIRECTmw:Help:Magic words#Other
This page is a soft redirect.-

C21H34O2
Molar mass 318.493
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Isopregnanolone (3β-hydroxy-5α-pregnan-20-one or 3β-hydroxy-5α-tetrahydroprogesterone; sometimes abbreviated as 3β,5α-THP), also known as sepranolone (INN), is an endogenous excitatory neurosteroid.[1] It appears to be a negative modulator of the GABAA receptor, and is known to have convulsant effects.[1][2] Isopregnanolone has been implicated in the pathology of depression and chronic fatigue syndrome, as well as other conditions.[1]

See also

References

  1. ^ a b c Murphy BE, Abbott FV, Allison CM, Watts C, Ghadirian AM (February 2004). "Elevated levels of some neuroactive progesterone metabolites, particularly isopregnanolone, in women with chronic fatigue syndrome". Psychoneuroendocrinology 29 (2): 245–68. PMID 14604604. doi:10.1016/s0306-4530(03)00026-x. 
  2. ^ Maitra R, Reynolds JN (September 1998). "Modulation of GABA(A) receptor function by neuroactive steroids: evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms". Can. J. Physiol. Pharmacol. 76 (9): 909–20. PMID 10066142. doi:10.1139/cjpp-76-9-909. 



Lua error in package.lua at line 80: module 'Module:Buffer' not found.