Adverts

Open Access Articles- Top Results for Istradefylline

Istradefylline

</th></tr>
Istradefylline
File:Istradefylline.svg
Systematic (IUPAC) name
8-[(E)-2-(3,4-dimethoxyphenyl)vinyl]-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione
Clinical data
Identifiers
155270-99-8 7pxY
None
PubChem CID 5311037
ChemSpider 4470574 7pxY
UNII 2GZ0LIK7T4 7pxY
KEGG D04641 7pxY
ChEMBL CHEMBL431770 7pxY
Chemical data
Formula C20H24N4O4
384.429 g/mol
 14pxY (what is this?)  (verify)

Istradefylline (KW-6002) is a selective antagonist at the A2A receptor. It has been found to be useful in the treatment of Parkinson's disease.[1] Istradefylline reduces dyskinesia resulting from long-term treatment with classical antiparkinson drugs such as levodopa. Istradefylline is an analog of caffeine.

References

  1. ^ Peter A. LeWitt, MD, M. Guttman, James W. Tetrud, MD, Paul J. Tuite, MD, Akihisa Mori, PhD, Philip Chaikin, PharmD, MD, Neil M. Sussman, MD (2008). "Adenosine A2A receptor antagonist istradefylline (KW-6002) reduces off time in Parkinson's disease: A double-blind, randomized, multicenter clinical trial (6002-US-005)". Annals of Neurology 63 (3): 295–302. PMID 18306243. doi:10.1002/ana.21315. 



Lua error in package.lua at line 80: module 'Module:Buffer' not found.