Adverts

Open Access Articles- Top Results for JARID1C

JARID1C

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsKDM5C ; DXS1272E; JARID1C; MRX13; MRXJ; MRXSCJ; MRXSJ; SMCX; XE169
External IDsOMIM314690 MGI99781 HomoloGene79498 IUPHAR: 2682 GeneCards: KDM5C Gene
RNA expression pattern
File:PBB GE JARID1C 202383 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez824220591
EnsemblENSG00000126012ENSMUSG00000025332
UniProtP41229P41230
RefSeq (mRNA)NM_001146702NM_013668
RefSeq (protein)NP_001140174NP_038696
Location (UCSC)Chr HG1433_PATCH:
52.93 – 52.97 Mb
Chr X:
152.23 – 152.27 Mb
PubMed search[1][2]

Lysine-specific demethylase 5C is an enzyme that in humans is encoded by the KDM5C gene.[1][2][3]

This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[3]

References

  1. ^ Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL, Bishop CE (Nov 1994). "A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human". Hum Mol Genet 3 (6): 879–84. PMID 7951230. doi:10.1093/hmg/3.6.879. 
  2. ^ Wu J, Ellison J, Salido E, Yen P, Mohandas T, Shapiro LJ (May 1994). "Isolation and characterization of XE169, a novel human gene that escapes X-inactivation". Hum Mol Genet 3 (1): 153–60. PMID 8162017. doi:10.1093/hmg/3.1.153. 
  3. ^ a b "Entrez Gene: JARID1C jumonji, AT rich interactive domain 1C". 

Further reading

</dl>

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Lua error in package.lua at line 80: module 'Module:Buffer' not found.