Open Access Articles- Top Results for JWH-122


Systematic (IUPAC) name
Clinical data
619294-47-2 7pxN
ChemSpider 24623066 7pxY
ChEMBL CHEMBL557004 7pxY
Chemical data
Formula C25H25NO
355.472 g/mol
 14pxN (what is this?)  (verify)

JWH-122 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is a methylated analogue of JWH-018. It has a Ki of 0.69 nM at CB1 and 1.2 nM at CB2.[1]

In January 2015, over 40 people were reportedly sickened after eating a holiday bread called Rosca de reyes purchased at a bakery in Santa Ana, CA that was laced with JWH-122.[2]

See also


  1. Huffman, J. et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.   edit

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