Open Access Articles- Top Results for JWH-149


Systematic (IUPAC) name
Clinical data
548461-82-1 7pxY
PubChem CID 45267820
ChemSpider 24627235
Chemical data
Formula C26H27NO
369.50 g/mol

JWH-149 is a synthetic cannabimimetic that was discovered by John W. Huffman. It is the N-pentyl analog of JWH-148. It is a potent but only moderately selective ligand for the CB2 receptor, with a binding affinity of Ki = 0.73 ± 0.03 nM at this subtype, and more than 6 times selectivity over the CB1 subtype.[1]

See also


  1. ^ Huffman, J. et al. (2005). "Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.". Bioorganic & Medicinal Chemistry 13 (1): 89–112. PMID 15582455. doi:10.1016/j.bmc.2004.09.050.   edit

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