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Open Access Articles- Top Results for JWH-251

JWH-251

JWH-251
200px
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This page is a soft redirect. Names

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IUPAC name
2-(2-methylphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone
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This page is a soft redirect. Identifiers#REDIRECTmw:Help:Magic words#Other
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864445-39-6 7pxN
ChEMBL ChEMBL364820 7pxY
ChemSpider 9791472 7pxY
Jmol-3D images Image
PubChem Template:Chembox PubChem/format
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This page is a soft redirect. Properties

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C22H25NO
Molar mass 319.440 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
 14pxN verify (what is10pxY/10pxN?)
Infobox references

JWH-251 (1-pentyl-3-(2-methylphenylacetyl)indole) is a synthetic cannabinoid from the phenylacetylindole family, which acts as a cannabinoid agonist with about 5x selectivity for CB1 with a Ki of 29nM and 146nM at CB2. Similar to the related 2'-methoxy compound JWH-250, the 2'-chloro compound JWH-203, and the 2'-bromo compound JWH-249, JWH-251 has a phenylacetyl group in place of the naphthoyl ring used in most aminoalkylindole cannabinoid compounds. [1][2]

References

  1. ^ Huffman, JW; Szklennik, PV; Almond, A; Bushell, K; Selley, DE; He, H; Cassidy, MP; Wiley, JL; Martin, BR (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & Medicinal Chemistry Letters 15 (18): 4110–3. PMID 16005223. doi:10.1016/j.bmcl.2005.06.008. 
  2. ^ Manera, C; Tuccinardi, T; Martinelli, A (2008). "Indoles and related compounds as cannabinoid ligands". Mini reviews in medicinal chemistry 8 (4): 370–87. PMID 18473928. doi:10.2174/138955708783955935. 


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