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James Rothman

James Rothman
Born James Edward Rothman
(1950-11-03) November 3, 1950 (age 65)
Haverhill, Massachusetts
Fields Cell biology
Alma mater Yale University, Harvard University
Doctoral advisor Template:If empty
Academic advisors Harvey Lodish
Notable awards Heinrich Wieland Prize (1990)
Richard Lounsbery Award (1997)
Louisa Gross Horwitz Prize (2002)
Albert Lasker Award for
Basic Medical Research
E. B. Wilson Medal (2010)
Nobel Prize in Physiology or Medicine (2013)

James Edward Rothman (born November 3, 1950) is the Fergus F. Wallace Professor of Biomedical Sciences at Yale University, the Chairman of the Department of Cell Biology at Yale School of Medicine, and the Director of the Nanobiology Institute at the Yale West Campus.[2] Rothman is also concurrently serving as adjunct professor of physiology and cellular biophysics at Columbia University.[3] and a research professor at the Institute of Neurology, University College, London.[4] Rothman was awarded the 2013 Nobel Prize in Physiology or Medicine, for his work on vesicle trafficking (shared with Randy Schekman and Thomas C. Südhof).[5] He has also received many other honors, including the King Faisal International Prize in 1996,[6] the Louisa Gross Horwitz Prize from Columbia University and the Albert Lasker Award for Basic Medical Research both in 2002.


Rothman graduated from the ivy academia in 1967 then received his B.A. in physics at Yale University in 1971 and his Ph.D. in biological chemistry at Harvard in 1976 working with Eugene Patrick Kennedy.[7] He then did his postdoctoral training with Harvey Lodish at Massachusetts Institute of Technology working on glycosylation of membrane proteins.[1][7]


Rothman began his career in the Department of Biochemistry at Stanford University in 1978. He was at Princeton University, from 1988 to 1991, before coming to New York to found the Department of Cellular Biochemistry and Biophysics at Memorial Sloan-Kettering Cancer Center, where he also served as vice chairman of Sloan-Kettering Institute. In 2003, he left Sloan-Kettering to become a professor of physiology at Columbia University's College of Physicians and Surgeons and the head of Columbia's Center for Chemical Biology.[8] He moved from Columbia to Yale in 2008, retaining a part-time appointment at Columbia.

Rothman is a member of the National Academy of Sciences and its Institute of Medicine.[7]

In 1995, Rothman joined the Amersham plc scientific advisory board. When Amersham was acquired by GE Healthcare in 2003, Rothman was appointed as the Chief Science Advisor to GE Healthcare.

Research and awards

File:Nobel prize for J.Rothman. Sthlm2013.JPG
Nobel Prize Ceremony: James Rothman receives his award from king of Sweden.

Rothman's research details how vesicles—tiny sac-like structures that transport hormones, growth factors, and other molecules within cells—know how to reach their correct destination and where and when to release their contents. This cellular trafficking underlies many critical physiological functions, including the propagation of the cell itself in division, communication between nerve cells in the brain, secretion of insulin and other hormones in the body, and nutrient uptake. Defects in this process lead to a wide variety of conditions, including diabetes and infectious diseases such as botulism.

Rothman was awarded the 2010 Kavli Prize Neuroscience together with Richard Scheller and Thomas C. Südhof for "discovering the molecular basis of neurotransmitters release".[9]

Rothman was awarded the 2013 Nobel prize in Physiology or Medicine together with Randy Schekman and Thomas C. Südhof for “their discoveries of machinery regulating vesicle traffic, a major transport system in our cells.”[10][11][12]


  1. ^ a b "James E. Rothman, Faculty: Yale Department of Chemistry". Retrieved 2013-10-07. 
  2. ^ "James E Rothman". Retrieved 7 October 2013. 
  3. ^ "P&S Adjunct Faculty Member Wins 2013 Nobel Prize". Columbia Newsroom. Retrieved 13 October 2013. 
  4. ^
  5. ^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Foundation. Retrieved October 7, 2013. 
  6. ^ "KFIP Winners Archive" (PDF). King Faisal Foundation. 
  7. ^ a b c "Yale’s James Rothman shares 2013 Nobel Prize in Physiology or Medicine". Yale News. 7 October 2013. Retrieved 7 October 2013. 
  8. ^ "Leading Cell Biologist Joins Columbia University College of Physicians & Surgeons". Columbia Medical Center Newsroom. Retrieved 13 October 2013. 
  9. ^ "JAMES ROTHMAN". 2010-09-06. Retrieved 2013-10-07. 
  10. ^ Altman, Lawrence (7 October 2013). "3 Win Joint Nobel Prize in Medicine". NY Times. Retrieved 7 October 2013. 
  11. ^ "James E. Rothman, Ph.D. ’76, Shares Nobel Prize for Medicine". Harvard Magazine. 7 October 2013. Retrieved 7 October 2013. 
  12. ^ "The Nobel Prize in Physiology or Medicine 2013". Nobel Prize. Retrieved 7 October 2013. 

External links

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