Open Access Articles- Top Results for KCND1


SymbolsKCND1 ; KV4.1
External IDsOMIM300281 MGI96671 HomoloGene21035 IUPHAR: 552 GeneCards: KCND1 Gene
RNA expression pattern
File:PBB GE KCND1 206842 at tn.png
More reference expression data
RefSeq (mRNA)NM_004979NM_008423
RefSeq (protein)NP_004970NP_032449
Location (UCSC)Chr HG1436_HG1432_PATCH:
48.82 – 48.83 Mb
Chr X:
7.82 – 7.84 Mb
PubMed search[1][2]

Potassium voltage-gated channel, Shal-related subfamily, member 1 (KCND1), also known as Kv4.1, is a human gene.[1]

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This gene is expressed at moderate levels in all tissues analyzed, with lower levels in skeletal muscle.[1]

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