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KCNIP1

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Identifiers
SymbolsKCNIP1 ; KCHIP1; VABP
External IDsOMIM604660 MGI1917607 HomoloGene22824 GeneCards: KCNIP1 Gene
RNA expression pattern
File:PBB GE KCNIP1 221307 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez3082070357
EnsemblENSG00000182132ENSMUSG00000053519
UniProtQ9NZI2Q9JJ57
RefSeq (mRNA)NM_001034837NM_001190885
RefSeq (protein)NP_001030009NP_001177814
Location (UCSC)Chr 5:
169.78 – 170.16 Mb
Chr 11:
33.63 – 33.99 Mb
PubMed search[1][2]

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[1][2]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

References

  1. ^ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature 403 (6769): 553–556. PMID 10676964. doi:10.1038/35000592. 
  2. ^ a b "Entrez Gene: KCNIP1 Kv channel interacting protein 1". 
  3. ^ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. PMC 1887812. PMID 17311005. doi:10.1038/nrn2093. 

See also

Further reading

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External links

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