Open Access Articles- Top Results for KCNK5


SymbolsKCNK5 ; K2p5.1; TASK-2; TASK2
External IDsOMIM603493 MGI1336175 HomoloGene2773 IUPHAR: 517 GeneCards: KCNK5 Gene
RNA expression pattern
File:PBB GE KCNK5 219615 s at tn.png
More reference expression data
RefSeq (mRNA)NM_003740NM_021542
RefSeq (protein)NP_003731NP_067517
Location (UCSC)Chr 6:
39.16 – 39.2 Mb
Chr 14:
20.14 – 20.18 Mb
PubMed search[1][2]

Potassium channel subfamily K member 5 is a protein that in humans is encoded by the KCNK5 gene.[1][2][3]

This gene encodes K2P5.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this gene is mainly expressed in the cortical distal tubules and collecting ducts of the kidney. The protein is highly sensitive to external pH and this, in combination with its expression pattern, suggests it may play an important role in renal potassium transport.[3]

See also


  1. ^ Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M (Dec 1998). "Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney". J Biol Chem 273 (47): 30863–9. PMID 9812978. doi:10.1074/jbc.273.47.30863. 
  2. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. PMID 16382106. doi:10.1124/pr.57.4.12. 
  3. ^ a b "Entrez Gene: KCNK5 potassium channel, subfamily K, member 5". 

Further reading


External links

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