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KCNK6

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Identifiers
SymbolsKCNK6 ; K2p6.1; KCNK8; TOSS; TWIK-2; TWIK2
External IDsOMIM603939 MGI1891291 HomoloGene31266 IUPHAR: 518 GeneCards: KCNK6 Gene
RNA expression pattern
File:PBB GE KCNK6 gnf1h00063 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez942452150
EnsemblENSG00000099337ENSMUSG00000046410
UniProtQ9Y257E9PXN4
RefSeq (mRNA)NM_004823NM_001033525
RefSeq (protein)NP_004814NP_001028697
Location (UCSC)Chr 19:
38.81 – 38.82 Mb
Chr 7:
29.22 – 29.23 Mb
PubMed search[1][2]

Potassium channel subfamily K member 6 is a protein that in humans is encoded by the KCNK6 gene.[1][2][3][4]

This gene encodes K2P6.1, one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered an open rectifier, is widely expressed. It is stimulated by arachidonic acid, and inhibited by internal acidification and volatile anaesthetics.[4]

See also

References

  1. ^ Chavez RA, Gray AT, Zhao BB, Kindler CH, Mazurek MJ, Mehta Y, Forsayeth JR, Yost CS (Apr 1999). "TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem 274 (12): 7887–92. PMID 10075682. doi:10.1074/jbc.274.12.7887. 
  2. ^ Gray AT, Kindler CH, Sampson ER, Yost CS (Jul 1999). "Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping". Cytogenet Cell Genet 84 (3–4): 190–1. PMID 10393428. doi:10.1159/000015255. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (Dec 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol Rev 57 (4): 527–40. PMID 16382106. doi:10.1124/pr.57.4.12. 
  4. ^ a b "Entrez Gene: KCNK6 potassium channel, subfamily K, member 6". 

Further reading

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External links

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