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KCNK7

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Identifiers
SymbolsKCNK7 ; K2p7.1; TWIK3
External IDsOMIM603940 MGI1341841 HomoloGene43131 IUPHAR: 519 GeneCards: KCNK7 Gene
Orthologs
SpeciesHumanMouse
Entrez1008916530
EnsemblENSG00000173338ENSMUSG00000024936
UniProtQ9Y2U2Q9Z2T1
RefSeq (mRNA)NM_005714NM_001004138
RefSeq (protein)NP_005705NP_034739
Location (UCSC)Chr 11:
65.36 – 65.36 Mb
Chr 19:
5.7 – 5.71 Mb
PubMed search[1][2]

Potassium channel, subfamily K, member 7, also known as KCNK7 or K2P7.1 is a protein which in humans is encoded by the KCNK7 gene. K2P7.1 is a potassium channel containing two pore-forming P domains.[1][2][3] Multiple transcript variants encoding different isoforms have been found for this gene.[4]

Function

This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product of this gene has not been shown to be a functional channel; It may require other non-pore-forming proteins for activity.[4]

See also

References

  1. ^ Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M (April 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem. 274 (17): 11751–60. PMID 10206991. doi:10.1074/jbc.274.17.11751. 
  2. ^ Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (March 2001). "Potassium leak channels and the KCNK family of two-P-domain subunits". Nat. Rev. Neurosci. 2 (3): 175–84. PMID 11256078. doi:10.1038/35058574. 
  3. ^ Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S (December 2005). "International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels". Pharmacol. Rev. 57 (4): 527–40. PMID 16382106. doi:10.1124/pr.57.4.12. 
  4. ^ a b "Entrez Gene: potassium channel". 

Further reading

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External links

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