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Open Access Articles- Top Results for KCNMB3

KCNMB3

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Identifiers
SymbolsKCNMB3 ; BKBETA3; HBETA3; K(VCA)BETA-3; KCNMB2; KCNMBL; SLO-BETA-3; SLOBETA3
External IDsOMIM605222 MGI3612244 HomoloGene18141 ChEMBL: 3934 GeneCards: KCNMB3 Gene
RNA expression pattern
File:PBB GE KCNMB3 221125 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez27094100502876
EnsemblENSG00000171121ENSMUSG00000091091
UniProtQ9NPA1E9Q7U0
RefSeq (mRNA)NM_001163677NM_001195074
RefSeq (protein)NP_001157149NP_001182003
Location (UCSC)Chr 3:
178.96 – 178.98 Mb
Chr 3:
32.47 – 32.49 Mb
PubMed search[1][2]

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.[1][2]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.[2]

See also

References

  1. ^ Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics 62 (1): 90–4. PMID 10585773. doi:10.1006/geno.1999.5975. 
  2. ^ a b "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3". 

Further reading

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