Open Access Articles- Top Results for KCNN4


SymbolsKCNN4 ; IK1; IKCA1; KCA4; KCa3.1; SK4; hIKCa1; hKCa4; hSK4
External IDsOMIM602754 MGI1277957 HomoloGene1696 IUPHAR: 384 ChEMBL: 4305 GeneCards: KCNN4 Gene
RNA expression pattern
File:PBB GE KCNN4 204401 at tn.png
More reference expression data
RefSeq (mRNA)NM_002250NM_001163510
RefSeq (protein)NP_002241NP_001156982
Location (UCSC)Chr 19:
44.27 – 44.29 Mb
Chr 7:
24.37 – 24.39 Mb
PubMed search[1][2]

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene encoding the KCa3.1 protein.[1]


The KCa3.1 protein is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane depolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.[1]


The channel activity was first described in 1958 by Gyorgi Gardos in human erythrocytes.[2] The channels is also named Gardos channel because of its discoverer.

See also


  1. ^ a b "Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4". 
  2. ^ Gardos G (1958). "The function of calcium in the potassium permeability of human erythrocytes". Biochim. Biophys. Acta 30 (3): 653–4. PMID 13618284. doi:10.1016/0006-3002(58)90124-0. 

Further reading


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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