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Open Access Articles- Top Results for KCNU1

KCNU1

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Identifiers
SymbolsKCNU1 ; KCNMC1; KCa5; KCa5.1; Kcnma3; Slo3
External IDsMGI1202300 HomoloGene7392 IUPHAR: 387 GeneCards: KCNU1 Gene
Orthologs
SpeciesHumanMouse
Entrez15785516532
EnsemblENSG00000215262ENSMUSG00000031576
UniProtA8MYU2O54982
RefSeq (mRNA)NM_001031836NM_008432
RefSeq (protein)NP_001027006NP_032458
Location (UCSC)Chr 8:
36.64 – 36.79 Mb
Chr 8:
25.85 – 25.94 Mb
PubMed search[1][2]

Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[1]

Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[2][3][4]

References

  1. ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (February 1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. PMID 9452476. doi:10.1074/jbc.273.6.3509. 
  2. ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels.". Pharmacol Rev 57 (4): 463–72. PMID 16382103. doi:10.1124/pr.57.4.9. 
  3. ^ Zhang X, Zeng X, Xia XM, Lingle CJ (September 2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. PMC 2151565. PMID 16940554. doi:10.1085/jgp.200609551. 
  4. ^ Zhang X, Zeng X, Lingle CJ (September 2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. PMC 2151566. PMID 16940555. doi:10.1085/jgp.200609552. 

Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).

Further reading

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Celia M. Santi, Alice Butler, Julia Kuhn, Aguan Wei, Lawrence Salkoff. Bovine and mouse SLO3 K+ channels: Evolutionary divergence points to a RCK1 region of critical function. J Biol Chem.284: 21589-98 (2009).


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