Open Access Articles- Top Results for KLF12


SymbolsKLF12 ; AP-2rep; AP2REP
External IDsOMIM607531 MGI1333796 HomoloGene21417 GeneCards: KLF12 Gene
RNA expression pattern
File:PBB GE KLF12 206966 s at tn.png
File:PBB GE KLF12 206965 at tn.png
File:PBB GE KLF12 214276 at tn.png
More reference expression data
RefSeq (mRNA)NM_007249NM_010636
RefSeq (protein)NP_009180NP_034766
Location (UCSC)Chr 13:
74.26 – 74.71 Mb
Chr 14:
99.87 – 100.15 Mb
PubMed search[1][2]

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.[1][2]

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.[2]

See also


  1. ^ Roth C, Schuierer M, Gunther K, Buettner R (Jul 2000). "Genomic structure and DNA binding properties of the human zinc finger transcriptional repressor AP-2rep (KLF12)". Genomics 63 (3): 384–90. PMID 10704285. doi:10.1006/geno.1999.6084. 
  2. ^ a b "Entrez Gene: KLF12 Kruppel-like factor 12". 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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