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Open Access Articles- Top Results for KLK1

KLK1

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Identifiers
SymbolsKLK1 ; KLKR; Klk6; hK1
External IDsOMIM147910 MGI97322 HomoloGene110727 ChEMBL: 2319 GeneCards: KLK1 Gene
EC number3.4.21.35
RNA expression pattern
File:PBB GE KLK1 216699 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez381618050
EnsemblENSG00000167748ENSMUSG00000066515
UniProtP06870Q62284
RefSeq (mRNA)NM_002257NM_008693
RefSeq (protein)NP_002248NP_032719
Location (UCSC)Chr 19:
51.32 – 51.33 Mb
Chr 7:
44.07 – 44.07 Mb
PubMed search[1][2]

Kallikrein-1 is a protein that in humans is encoded by the KLK1 gene.[1][2][3] KLK1 is a member of the peptidase S1 family.

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.[4]

References

  1. ^ Richards RI, Holman K, Shen Y, Kozman H, Harley H, Brook D, Shaw D (Feb 1992). "Human glandular Kallikrein genes: genetic and physical mapping of the KLK1 locus using a highly polymorphic microsatellite PCR marker". Genomics 11 (1): 77–82. PMID 1684954. doi:10.1016/0888-7543(91)90103-L. 
  2. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. PMID 16800724. doi:10.1515/BC.2006.082. 
  3. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. PMID 16800723. doi:10.1515/BC.2006.081. 
  4. ^ "Entrez Gene: KLK1 kallikrein 1". 

Further reading

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External links

  • The MEROPS online database for peptidases and their inhibitors: S01.160

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