Open Access Articles- Top Results for KRT81


SymbolsKRT81 ; HB1; Hb-1; KRTHB1; MLN137; ghHkb1; hHAKB2-1
External IDsOMIM602153 HomoloGene55645 GeneCards: KRT81 Gene
RNA expression pattern
File:PBB GE KRT81 213711 at tn.png
More reference expression data
RefSeq (mRNA)NM_002281NM_001166157
RefSeq (protein)NP_002272NP_001159629
Location (UCSC)Chr 12:
52.68 – 52.69 Mb
Chr 15:
101.46 – 101.46 Mb
PubMed search[1][2]

Keratin, type II cuticular Hb1 is a protein that in humans is encoded by the KRT81 gene.[1][2][3]

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB3 and KRTHB6, is found primarily in the hair cortex. Mutations in this gene and KRTHB6 have been observed in patients with a rare dominant hair disease, monilethrix.[3]


  1. Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res 220 (2): 357–62. PMID 7556444. doi:10.1006/excr.1995.1326. 
  2. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74. PMC 2064177. PMID 16831889. doi:10.1083/jcb.200603161. 
  3. 3.0 3.1 "Entrez Gene: KRT81 keratin 81". 

Further reading


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