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Open Access Articles- Top Results for Keratocan

Keratocan

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Identifiers
SymbolsKERA ; CNA2; KTN; SLRR2B
External IDsOMIM603288 MGI1202398 HomoloGene5106 GeneCards: KERA Gene
RNA expression pattern
File:PBB GE KERA 220504 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez1108116545
EnsemblENSG00000139330ENSMUSG00000019932
UniProtO60938O35367
RefSeq (mRNA)NM_007035NM_008438
RefSeq (protein)NP_008966NP_032464
Location (UCSC)Chr 12:
91.44 – 91.45 Mb
Chr 10:
97.61 – 97.61 Mb
PubMed search[1][2]

Keratocan (KTN) also known as keratan sulfate proteoglycan keratocan is a protein that in humans is encoded by the KERA gene.[1][2][3]

Keratan sulfate proteoglycans (KSPGs) are members of the small leucine-rich proteoglycan (SLRP) family. KSPGs, particularly keratocan, lumican and mimecan, are important to the transparency of the cornea.[3]

Mutations of the gene cause cornea plana 2.

References

  1. ^ Tasheva ES, Funderburgh JL, Funderburgh ML, Corpuz LM, Conrad GW (Jan 2000). "Structure and sequence of the gene encoding human keratocan". DNA Seq 10 (1): 67–74. PMID 10565548. doi:10.3109/10425179909033939. 
  2. ^ Pellegata NS, Dieguez-Lucena JL, Joensuu T, Lau S, Montgomery KT, Krahe R, Kivela T, Kucherlapati R, Forsius H, de la Chapelle A (Jun 2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat Genet 25 (1): 91–5. PMID 10802664. doi:10.1038/75664. 
  3. ^ a b "Entrez Gene: KERA keratocan". 

Further reading

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