Adverts

Open Access Articles- Top Results for Ketazocine

Ketazocine

</th></tr>
Ketazocine
File:Ketazocine structure.svg
Systematic (IUPAC) name
(2S,6R,11R)-3-(cyclopropylmethyl)-8-hydroxy-6,11-dimethyl-3,4,5,6-tetrahydro-2,6-methano-3-benzazocin-1(2H)-one
Clinical data
  •  ?
Oral
Identifiers
36292-69-0 7pxY
None
PubChem CID 3054741
ChemSpider 2316328 7pxY
UNII 6IO4IG518S 7pxY
KEGG D04649 7pxY
Chemical data
Formula C18H23NO2
285.38 g/mol
 14pxY (what is this?)  (verify)

Ketazocine (INN), also known as ketocyclazocine, is a benzomorphan derivative used in opioid receptor research. Ketocyclazocine is an exogenous opioid that binds to the kappa opioid receptor.[1]

Activation of this receptor is known to cause sleepiness, a decrease in pain sensation and (potentially) dysphoria, paranoia, and hallucinations. It also causes an increase in urine production because it inhibits the release of vasopressin. (Vasopressin is an endogenous substance that assists in regulating fluid and electrolyte balance in the body and decreases the amount of water released into the urine.)

Unlike other opioids, substances that only bind to the kappa receptor theoretically do not depress the respiratory system.

See also

References

  1. ^ Leander JD (Sep 1982). "Effects of ketazocine, ethylketazocine and phenazocine on schedule-controlled behavior: antagonism by naloxone". Neuropharmacology 21 (9): 923–8. PMID 6128693. doi:10.1016/0028-3908(82)90085-5. 


Template:Opioidergics