Open Access Articles- Top Results for Kinase insert domain receptor

Kinase insert domain receptor

SymbolsKDR ; CD309; FLK1; VEGFR; VEGFR2
External IDsOMIM191306 MGI96683 HomoloGene55639 IUPHAR: 1813 ChEMBL: 279 GeneCards: KDR Gene
EC number2.7.10.1
RNA expression pattern
File:PBB GE KDR 203934 at tn.png
More reference expression data
RefSeq (mRNA)NM_002253NM_010612
RefSeq (protein)NP_002244NP_034742
Location (UCSC)Chr 4:
55.94 – 55.99 Mb
Chr 5:
75.93 – 75.98 Mb
PubMed search[1][2]

Kinase insert domain receptor (KDR, a type III receptor tyrosine kinase) also known as vascular endothelial growth factor receptor 2 (VEGFR-2) is a VEGF receptor. KDR is the human gene encoding it. KDR has also been designated as CD309 (cluster of differentiation 309). KDR is also known as Flk1 (Fetal Liver Kinase 1).


Kinase insert domain receptor has been shown to interact with SHC2,[1] Annexin A5[2] and SHC1.[3][4]

See also

Further reading



  1. ^ Warner, A J; Lopez-Dee J; Knight E L; Feramisco J R; Prigent S A (April 2000). "The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells". Biochem. J. (England) 347 (Pt 2): 501–9. ISSN 0264-6021. PMC 1220983. PMID 10749680. doi:10.1042/0264-6021:3470501. 
  2. ^ Wen, Y; Edelman J L; Kang T; Sachs G (May 1999). "Lipocortin V may function as a signaling protein for vascular endothelial growth factor receptor-2/Flk-1". Biochem. Biophys. Res. Commun. (UNITED STATES) 258 (3): 713–21. ISSN 0006-291X. PMID 10329451. doi:10.1006/bbrc.1999.0678. 
  3. ^ Zanetti, Adriana; Lampugnani Maria Grazia; Balconi Giovanna; Breviario Ferruccio; Corada Monica; Lanfrancone Luisa; Dejana Elisabetta (April 2002). "Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling". Arterioscler. Thromb. Vasc. Biol. (United States) 22 (4): 617–22. PMID 11950700. doi:10.1161/01.ATV.0000012268.84961.AD. 
  4. ^ D'Angelo, G; Martini J F; Iiri T; Fantl W J; Martial J; Weiner R I (May 1999). "16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells". Mol. Endocrinol. (UNITED STATES) 13 (5): 692–704. ISSN 0888-8809. PMID 10319320. doi:10.1210/mend.13.5.0280. 

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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