Open Access Articles- Top Results for KvLQT3


SymbolsKCNQ3 ; BFNC2; EBN2; KV7.3
External IDsOMIM602232 MGI1336181 HomoloGene20949 IUPHAR: 562 ChEMBL: 2684 GeneCards: KCNQ3 Gene
RNA expression pattern
File:PBB GE KCNQ3 206573 at tn.png
More reference expression data
RefSeq (mRNA)NM_001204824NM_152923
RefSeq (protein)NP_001191753NP_690887
Location (UCSC)Chr 8:
133.13 – 133.49 Mb
Chr 15:
65.99 – 66.29 Mb
PubMed search[1][2]

Kv7.3 (KvLQT3) is a potassium channel protein coded for by the gene KCNQ3.[1]

It is associated with benign familial neonatal epilepsy.

The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and one of two related proteins encoded by the KCNQ2 and KCNQ5 genes, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 2 (BFNC2), also known as epilepsy, benign neonatal type 2 (EBN2).[1]


KvLQT3 has been shown to interact with KCNQ5.[2]


  1. ^ a b "Entrez Gene: KCNQ3 potassium voltage-gated channel, KQT-like subfamily, member 3". 
  2. ^ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience (United States) 120 (2): 353–64. ISSN 0306-4522. PMID 12890507. doi:10.1016/S0306-4522(03)00321-X. 

Further reading


External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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