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Open Access Articles- Top Results for L-694247

L-694247

L-694247
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IUPAC name
(2-[5-[3-(4-methylsulphonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indole-3-yl]ethylamine)
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C20H21N5O3S
Molar mass 411.48 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

L-694247 is a somewhat selective 5-HT1D agonist, with a 10-fold greater affinity for the 5-HT1B receptor, and 25-fold greater affinity for the 5-HT1A receptor.[1] When L-694247 was injected intraventricularly in dehydrated rats, it inhibited water intake. Pre-treatment with a 5-HT1D antagonist abolished this effect. Administration of L-694,247 to normally hydrated rats had no effect on water intake.[2]

References

  1. ^ Beer, MS (November 1993). "L-694,247: a potent 5-HT1D receptor agonist.". British Journal of Pharmacology 110 (3): 1196–200. PMC 2175804. PMID 8298808. doi:10.1111/j.1476-5381.1993.tb13941.x. Retrieved 7 January 2012. 
  2. ^ CASTRO-e-SILVA, E. DE (August 1997). "Effect of Third Ventricle Administration of L-694,247, a Selective 5-HT1D Receptor Agonist, on Water Intake in Rats". Pharmacology, Biochemistry and Behavior 57 (4): 749–754. doi:10.1016/S0091-3057(96)00457-1. 



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