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Open Access Articles- Top Results for L1 (protein)

L1 (protein)

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Identifiers
SymbolsL1CAM ; CAML1; CD171; HSAS; HSAS1; MASA; MIC5; N-CAM-L1; N-CAML1; NCAM-L1; S10; SPG1
External IDsOMIM308840 MGI96721 HomoloGene20128 GeneCards: L1CAM Gene
RNA expression pattern
File:PBB GE L1CAM 204584 at tn.png
File:PBB GE L1CAM 204585 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez389716728
EnsemblENSG00000198910ENSMUSG00000031391
UniProtP32004n/a
RefSeq (mRNA)NM_000425NM_008478
RefSeq (protein)NP_000416NP_032504
Location (UCSC)Chr HG1497_PATCH:
153.03 – 153.08 Mb
Chr X:
73.85 – 73.9 Mb
PubMed search[1][2]

L1, also known as L1CAM, is a transmembrane protein; it is a neuronal cell adhesion molecule, member of the L1 protein family, of 200-220 kDa, and involved in axon guidance and cell migration with a strong implication in treatment-resistant cancers.

L1CAM has also been designated CD171 (cluster of differentiation 171).

The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin superfamily of proteins. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration, and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.[1]

Interactions

L1 (protein) has been shown to interact with NUMB.[2]

References

  1. ^ "Entrez Gene: L1CAM L1 cell adhesion molecule". 
  2. ^ Nishimura, Takashi; Fukata Yuko; Kato Katsuhiro; Yamaguchi Tomoya; Matsuura Yoshiharu; Kamiguchi Hiroyuki; Kaibuchi Kozo (Sep 2003). "CRMP-2 regulates polarized Numb-mediated endocytosis for axon growth". Nat. Cell Biol. (England) 5 (9): 819–26. ISSN 1465-7392. PMID 12942088. doi:10.1038/ncb1039. 

Further reading

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External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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