Adverts

Open Access Articles- Top Results for LAIR1

LAIR1

Template:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/rowTemplate:Infobox3cols/row
Identifiers
SymbolsLAIR1 ; CD305; LAIR-1
External IDsOMIM602992 MGI105492 HomoloGene48097 GeneCards: LAIR1 Gene
RNA expression pattern
File:PBB GE LAIR1 210644 s at tn.png
File:PBB GE LAIR1 208071 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez390352855
EnsemblENSG00000167613ENSMUSG00000055541
UniProtQ6GTX8Q8BG84
RefSeq (mRNA)NM_001289023NM_001113474
RefSeq (protein)NP_001275952NP_001106945
Location (UCSC)Chr 19:
54.87 – 54.88 Mb
Chr 7:
4.01 – 4.06 Mb
PubMed search[1][2]

Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene.[1][2] LAIR1 has also been designated as CD305 (cluster of differentiation 305).

Function

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.[2]

Interactions

LAIR1 has been shown to interact with PTPN11[1][3] and PTPN6.[1][3][4][5][6]

References

  1. ^ a b c Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL et al. (September 1997). "LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes". Immunity 7 (2): 283–90. PMID 9285412. doi:10.1016/S1074-7613(00)80530-0. 
  2. ^ a b "Entrez Gene: LAIR1 leukocyte-associated immunoglobulin-like receptor 1". 
  3. ^ a b Fournier N, Chalus L, Durand I, Garcia E, Pin JJ, Churakova T et al. (August 2000). "FDF03, a novel inhibitory receptor of the immunoglobulin superfamily, is expressed by human dendritic and myeloid cells". J. Immunol. 165 (3): 1197–209. PMID 10903717. doi:10.4049/jimmunol.165.3.1197. 
  4. ^ Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ et al. (February 2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. PMID 11160222. doi:10.4049/jimmunol.166.3.1763. 
  5. ^ Mousseau DD, Banville D, L'Abbé D, Bouchard P, Shen SH (February 2000). "PILRalpha, a novel immunoreceptor tyrosine-based inhibitory motif-bearing protein, recruits SHP-1 upon tyrosine phosphorylation and is paired with the truncated counterpart PILRbeta". J. Biol. Chem. 275 (6): 4467–74. PMID 10660620. doi:10.1074/jbc.275.6.4467. 
  6. ^ Xu M, Zhao R, Zhao ZJ (June 2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. PMID 10764762. doi:10.1074/jbc.M001313200. 

Further reading

  • Sinclair NR (1999). "Why so many coinhibitory receptors?". Scand. J. Immunol. 50 (1): 10–3. PMID 10404045. doi:10.1046/j.1365-3083.1999.00580.x. 
  • Meyaard L (1999). "LAIR-1, a widely distributed human ITIM-bearing receptor on hematopoietic cells". Curr. Top. Microbiol. Immunol. Current Topics in Microbiology 244 and Immunology 244: 151–7. ISBN 978-3-540-65789-7. PMID 10453657. doi:10.1007/978-3-642-58537-1_13. 
  • Meyaard L (2004). "Leukocyte associated Ig-like receptor (LAIR)". J. Biol. Regul. Homeost. Agents 17 (4): 330–3. PMID 15065762. 
  • Poggi A, Tomasello E, Ferrero E, Zocchi MR, Moretta L (1998). "p40/LAIR-1 regulates the differentiation of peripheral blood precursors to dendritic cells induced by granulocyte-monocyte colony-stimulating factor". Eur. J. Immunol. 28 (7): 2086–91. PMID 9692876. doi:10.1002/(SICI)1521-4141(199807)28:07<2086::AID-IMMU2086>3.0.CO;2-T. 
  • Meyaard L, Hurenkamp J, Clevers H, Lanier LL, Phillips JH (1999). "Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells". J. Immunol. 162 (10): 5800–4. PMID 10229813. 
  • van der Vuurst de Vries AR, Clevers H, Logtenberg T, Meyaard L (1999). "Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling". Eur. J. Immunol. 29 (10): 3160–7. PMID 10540327. doi:10.1002/(SICI)1521-4141(199910)29:10<3160::AID-IMMU3160>3.0.CO;2-S. 
  • Xu M, Zhao R, Zhao ZJ (2000). "Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells". J. Biol. Chem. 275 (23): 17440–6. PMID 10764762. doi:10.1074/jbc.M001313200. 
  • Poggi A, Pellegatta F, Leone BE, Moretta L, Zocchi MR (2000). "Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias". Eur. J. Immunol. 30 (10): 2751–8. PMID 11069054. doi:10.1002/1521-4141(200010)30:10<2751::AID-IMMU2751>3.0.CO;2-L. 
  • Sathish JG, Johnson KG, Fuller KJ, LeRoy FG, Meyaard L, Sims MJ et al. (2001). "Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells". J. Immunol. 166 (3): 1763–70. PMID 11160222. doi:10.4049/jimmunol.166.3.1763. 
  • Saverino D, Fabbi M, Merlo A, Ravera G, Grossi CE, Ciccone E (2002). "Surface density expression of the leukocyte-associated Ig-like receptor-1 is directly related to inhibition of human T-cell functions". Hum. Immunol. 63 (7): 534–46. PMID 12072189. doi:10.1016/S0198-8859(02)00409-3. 
  • Aoukaty A, Lee IF, Wu J, Tan R (2003). "Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells". J. Clin. Immunol. 23 (2): 141–5. PMID 12757266. doi:10.1023/A:1022580929226. 
  • Verbrugge A, Ruiter Td T, Clevers H, Meyaard L (2003). "Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment". Int. Immunol. 15 (11): 1349–58. PMID 14565933. doi:10.1093/intimm/dxg134. 
  • De Milito A, Nilsson A, Titanji K, Thorstensson R, Reizenstein E, Narita M et al. (2004). "Mechanisms of hypergammaglobulinemia and impaired antigen-specific humoral immunity in HIV-1 infection". Blood 103 (6): 2180–6. PMID 14604962. doi:10.1182/blood-2003-07-2375. 
</dl>

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Lua error in package.lua at line 80: module 'Module:Buffer' not found. Lua error in package.lua at line 80: module 'Module:Buffer' not found.