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Open Access Articles- Top Results for LATS2

LATS2

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Identifiers
SymbolsLATS2 ; KPM
External IDsOMIM604861 MGI1354386 HomoloGene56678 IUPHAR: 1516 ChEMBL: 5907 GeneCards: LATS2 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE LATS2 gnf1h02724 s at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez2652450523
EnsemblENSG00000150457ENSMUSG00000021959
UniProtQ9NRM7Q7TSJ6
RefSeq (mRNA)NM_014572NM_015771
RefSeq (protein)NP_055387NP_056586
Location (UCSC)Chr 13:
21.55 – 21.64 Mb
Chr 14:
57.64 – 57.76 Mb
PubMed search[1][2]

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.[1][2]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.[2]

References

  1. Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics 63 (2): 263–70. PMID 10673337. doi:10.1006/geno.1999.6065. 
  2. 2.0 2.1 "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)". 

Further reading

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