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Open Access Articles- Top Results for LMTK2

LMTK2

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Identifiers
SymbolsLMTK2 ; AATYK2; BREK; KPI-2; KPI2; LMR2; PPP1R100; cprk
External IDsOMIM610989 MGI3036247 HomoloGene8948 IUPHAR: 2056 GeneCards: LMTK2 Gene
EC number2.7.11.1
RNA expression pattern
File:PBB GE LMTK2 206223 at tn.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez22853231876
EnsemblENSG00000164715ENSMUSG00000038970
UniProtQ8IWU2Q3TYD6
RefSeq (mRNA)NM_014916NM_001081109
RefSeq (protein)NP_055731NP_001074578
Location (UCSC)Chr 7:
97.74 – 97.84 Mb
Chr 5:
144.1 – 144.19 Mb
PubMed search[1][2]

Serine/threonine-protein kinase LMTK2 also known as Lemur tyrosine kinase 2 (LMTK2) is an enzyme that in humans is encoded by the LMTK2 gene.[1][2]

Function

The LMTK2 enzyme belongs to both the protein kinase and the tyrosine kinase families. It contains N-terminus transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein is involved in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis.[2]

Interactions

LMTK2 has been shown to interact with PPP1CA,[3] Cyclin-dependent kinase 5[4] and PPP1R2.[3]

References

  1. ^ Kawa S, Fujimoto J, Tezuka T, Nakazawa T, Yamamoto T (Mar 2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling". Genes Cells 9 (3): 219–32. PMID 15005709. doi:10.1111/j.1356-9597.2004.00714.x. 
  2. ^ a b "Entrez Gene: LMTK2 lemur tyrosine kinase 2". 
  3. ^ a b Wang, Hong; Brautigan David L (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". J. Biol. Chem. (United States) 277 (51): 49605–12. ISSN 0021-9258. PMID 12393858. doi:10.1074/jbc.M209335200. 
  4. ^ Kesavapany, Sashi; Lau Kwok-Fai; Ackerley Steven; Banner Steven J; Shemilt Stephen J A; Cooper Jonathan D; Leigh P Nigel; Shaw Christopher E; McLoughlin Declan M; Miller Christopher C J (Jun 2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase". J. Neurosci. (United States) 23 (12): 4975–83. PMID 12832520. 

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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