Open Access Articles- Top Results for LPAR5


SymbolsLPAR5 ; GPR92; GPR93; KPG_010; LPA5
External IDsOMIM606926 MGI2685918 HomoloGene10696 IUPHAR: 124 ChEMBL: 5700 GeneCards: LPAR5 Gene
RefSeq (mRNA)NM_001142961NM_001163268
RefSeq (protein)NP_001136433NP_001156740
Location (UCSC)Chr 12:
6.73 – 6.75 Mb
Chr 6:
125.07 – 125.08 Mb
PubMed search[1][2]

Lysophosphatidic acid receptor 5 also known as LPA5 is a protein that in humans is encoded by the LPAR5 gene.[1][2][3][4][5] LPA5 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[6]

See also


  1. ^ "Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23". Nat Genet 26 (3): 345–8. Dec 2000. PMID 11062477. doi:10.1038/81664. 
  2. ^ Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O et al. (Sep 2001). "Discovery and mapping of ten novel G protein-coupled receptor genes". Gene 275 (1): 83–91. PMID 11574155. doi:10.1016/S0378-1119(01)00651-5. 
  3. ^ Lee CW, Rivera R, Gardell S, Dubin AE, Chun J (Aug 2006). "GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5". J Biol Chem 281 (33): 23589–97. PMID 16774927. doi:10.1074/jbc.M603670200. 
  4. ^ Kotarsky K, Boketoft A, Bristulf J, Nilsson NE, Norberg A, Hansson S et al. (Jul 2006). "Lysophosphatidic acid binds to and activates GPR92, a G protein-coupled receptor highly expressed in gastrointestinal lymphocytes". J Pharmacol Exp Ther 318 (2): 619–28. PMID 16651401. doi:10.1124/jpet.105.098848. 
  5. ^ "Entrez Gene: GPR92 G protein-coupled receptor 92". 
  6. ^ Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T et al. (January 2010). "LPA Receptors: Subtypes and Biological Actions". Annual Review of Pharmacology and Toxicology 50 (1): 157–186. PMID 20055701. doi:10.1146/annurev.pharmtox.010909.105753. 

Further reading

  • Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Lett. 520 (1–3): 97–101. PMID 12044878. doi:10.1016/S0014-5793(02)02775-8. 

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