Open Access Articles- Top Results for LPHN2


SymbolsLPHN2 ; CIRL2; CL2; LEC1; LPHH1
External IDsOMIM607018 MGI2139714 HomoloGene22712 IUPHAR: 207 GeneCards: LPHN2 Gene
RNA expression pattern
File:PBB GE LPHN2 206953 s at tn.png
More reference expression data
RefSeq (mRNA)NM_001297704NM_001081298
RefSeq (protein)NP_001284633NP_001074767
Location (UCSC)Chr 1:
81.77 – 82.46 Mb
Chr 3:
148.82 – 148.99 Mb
PubMed search[1][2]

Latrophilin-2 is a protein that in humans is encoded by the LPHN2 gene.[1][2]

This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.[2]

See also


  1. ^ White GR, Varley JM, Heighway J (Jul 2000). "Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines". Biochim Biophys Acta 1491 (1-3): 75–92. PMID 10760572. doi:10.1016/s0167-4781(00)00020-8. 
  2. ^ a b "Entrez Gene: LPHN2 latrophilin 2". 

Further reading

  • Südhof TC (2001). "alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.". Annu. Rev. Neurosci. 24 (1): 933–62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933. 
  • Ushkaryov YA, Volynski KE, Ashton AC (2004). "The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.". Toxicon 43 (5): 527–42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791. 
  • Nagase T, Ishikawa K, Suyama M et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277. 
  • White GR, Varley JM, Heighway J (1999). "Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer.". Oncogene 17 (26): 3513–9. PMID 10030676. doi:10.1038/sj.onc.1202487. 
  • Kreienkamp HJ, Zitzer H, Gundelfinger ED et al. (2000). "The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.". J. Biol. Chem. 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200. 
  • Bjarnadóttir TK, Fredriksson R, Höglund PJ et al. (2005). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors.". Genomics 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004. 
  • Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. PMID 16710414. doi:10.1038/nature04727. 
  • Clark TA, Schweitzer AC, Chen TX et al. (2007). "Discovery of tissue-specific exons using comprehensive human exon microarrays.". Genome Biol. 8 (4): R64. PMC 1896007. PMID 17456239. doi:10.1186/gb-2007-8-4-r64. 

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