Open Access Articles- Top Results for LY-307,452


Systematic (IUPAC) name
(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)pentan-1,5-dioic acid
Clinical data
PubChem CID 6324634
ChemSpider 4884363 7pxN
Chemical data
Formula C21H25NO4
355.428 g/mol
 14pxN (what is this?)  (verify)

LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3),[1] and was useful in early studies of this receptor family,[2][3] although it has largely been replaced by newer drugs such as LY-341,495.


  1. ^ Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD (February 1996). "(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase". Journal of Medicinal Chemistry 39 (4): 814–6. PMID 8632404. doi:10.1021/jm9508144. 
  2. ^ Li XC, Beart PM, Monn JA, Jones NM, Widdop RE (October 1999). "Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats". British Journal of Pharmacology 128 (3): 823–9. PMC 1571690. PMID 10516668. doi:10.1038/sj.bjp.0702850. 
  3. ^ Sung KW, Choi S, Lovinger DM (November 2001). "Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses". Journal of Neurophysiology 86 (5): 2405–12. PMID 11698530. 

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