Lactobacillus - Related Links
Open Access Articles- Top Results for Lactobacillus
Journal of Bioequivalence & BioavailabilityScreening and In-Vitro Analysis of Lactobacillus reuteri Strains for Short Chain Fatty Acids Production, Stability and Therapeutic Potentials in Col
Research & Reviews: Journal of Microbiology and BiotechnologyCarbohydrate Utilization Profiles of Lactobacillus Isolates from Marine Waters of Bay of Bengal near Krishnapatnam Port, Nellore District, Andhra Prad
Advances in Dairy ResearchProbiotic LaVK2 Dahi Improves Lipid Profiles in Hypercholesterolemic Rats
Journal of Probiotics & HealthEffect of Lactobacillus plantarum Strains on Clinical Isolates of Clostridium difficile in vitro
Journal of Probiotics & HealthMaternal Gut Microbes Control Offspring Sex and Survival
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Lactobacillus, also called "Döderlein's bacillus", is a genus of Gram-positive facultative anaerobic or microaerophilic rod-shaped bacteria. They are a major part of the lactic acid bacteria group. In humans they are part of the vaginal microbiota. Many species in this genus have had their genome sequenced.
Biology and biochemistry
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Lactobacillus is Gram-positive (they retain crystal violet dye), facultative anaerobe (they can produce energy through glycolysis and fermentation when oxygen is not present). Lactobacillus is a member of the lactic acid bacteria group (its members convert lactose and other sugars to lactic acid).
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Many lactobacilli operate using homofermentative metabolism (they produce only lactic acid from sugars), and some species of lactobacilli use heterofermentative metabolism (they can produce either alcohol or lactic acid from sugars). They are aerotolerant despite the complete absence of a respiratory chain. This aerotolerance is manganese-dependent and has been explored (and explained) in Lactobacillus plantarum. Many lactobacilli do not require iron for growth and have an extremely high hydrogen peroxide tolerance.
The genus Lactobacillus currently consists of over 180 species and encompasses a wide variety of organisms. The genus is polyphyletic, with the genus Pediococcus dividing the L. casei group, and the species L. acidophilus, L. salivarius, and L. reuteri being representatives of three distinct subclades. The genus Paralactobacillus falls within the L. salivarius group. In recent years, other members of the genus Lactobacillus (formerly known as the Leuconostoc branch of Lactobacillus) have been reclassified into the genera Atopobium, Carnobacterium, Weissella, Oenococcus, and Leuconostoc. More recently, the Pediococcus species P. dextrinicus has been reclassified as a Lactobacillus species (IJSEM, Paper in Press).
According to metabolism, Lactobacillus species can be divided into three groups:
- Obligately homofermentative (Group I) including:
- Facultatively heterofermentative (Group II) including:
- Obligately heterofermentative (Group III) including:
Usage in humans
EffectivenessLactobacillus is a type of bacteria with multiple different species in the genus. Most Lactobacillus in humans are considered un-harmful. Lactobacilli live in the urinary, digestive and genital tracks of humans. Lactobacillus is possibly effective for preventing diarrhea in children, or a bacterial vaginal infections. However, it may be possibly ineffective for UTI's, lactose intolerance, and yeast infections. 
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Probiotics and biotherapeuticsSome strains of Lactobacillus spp. and other lactic acid bacteria may possess potential therapeutic properties including anti-inflammatory and anti-cancer activities, as well as other features of interest. A study by researchers from the Beth Israel Deaconess Medical Center and UCLA in 2009 demonstrated the protective effects of some strains of these bacteria for anti-tumor and anti-cancer effects in mice.
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Lactobacilli can also be used to restore particular physiological balance such as in the vaginal eco-system. Their role is (1) to physically protect the vaginal epithelium by building a thick layer separating the epithelium from pathogens, (2) to physiologically keep the balance of the vaginal ecosystem in maintaining the pH at ~4.5, and (3) generating hydrogen peroxide against pathogens. Lactobacilli are highly tolerant to low pH and can easily maintain low pH and protect the vaginal eco-system from Gram-negative and Gram-positive bacteria.
Some Lactobacillus species are used as starter cultures in industry for controlled fermentation in the production of yogurt, cheese, sauerkraut, pickles, beer, wine, cider, kimchi, cocoa, kefir, and other fermented foods, as well as animal feeds. The antibacterial and anti fungal activity of "Lactobacillus" rely on production of bacteriocins and low-molecular weight compounds that inhibits these microorganisms. 
Sourdough bread is made using a "starter culture," which is a symbiotic culture of yeast and lactic acid bacteria growing in a water and flour medium. The bacteria metabolize sugars into lactic acid, which lowers the pH of their environment, creating a signature "sourness" associated with yogurt, sauerkraut, etc.
In many traditional pickling processes, vegetables are submerged in brine, and salt-tolerant lactobacillus species feed on natural sugars found in the vegetables. The resulting mix of salt and lactic acid is a hostile environment for other microbes, such as fungi, and the vegetables are thus preserved -- remaining edible for long periods.
Lactobacilli, especially L. casei and L. brevis, are some of the most common beer spoilage organisms. They are however essential to the production of sour beers such as Belgian Lambics and American Wild Ales, giving the beer a distinct tart flavor.
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While streptococci family bacteria (e.g. Streptococcus mutans) are the main cause of tooth decay, other varieties of microbes can cause dental caries, but to a lesser extent. For example, although considered beneficial, some Lactobacillus species have been associated with dental caries. The Lactobacillus count in saliva has been used as a "caries test" for many years. This is one of the arguments used in support of the use of fluoride in toothpaste. Lactobacilli characteristically cause existing carious lesions to progress, especially those in coronal caries. The issue is, however, complex as recent studies show probiotics can allow beneficial lactobacilli to populate sites on teeth, preventing streptococci pathogens from taking hold and inducing dental decay.
- Lactic acid bacteria
- Lactic acid fermentation
- MRS agar
- Makarova, K.; Slesarev, A.; Wolf, Y.; Sorokin, A.; Mirkin, B.; Koonin, E.; Pavlov, A.; Pavlova, N. et al. (Oct 2006). "Comparative genomics of the lactic acid bacteria". Proc Natl Acad Sci U S A 103 (42): 15611–6. PMC 1622870. PMID 17030793. doi:10.1073/pnas.0607117103.
- Petrova, Mariya I.; Lievens, Elke; Malik, Shweta; Imholz, Nicole; Lebeer, Sarah (2015). "Lactobacillus species as biomarkers and agents that can promote various aspects of vaginal health". Frontiers in Physiology 6. ISSN 1664-042X. doi:10.3389/fphys.2015.00081.
- Fijan, Sabina (2014). "Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature". International Journal of Environmental Research and Public Health 11 (5): 4745–4767. ISSN 1660-4601. doi:10.3390/ijerph110504745.
- Chen, X.; Fruehauf, J.; Goldsmith, J. D.; Xu, H.; Katchar, K. K.; Koon, H. W.; Zhao, D.; Kokkotou, E. G.; Pothoulakis, C.; Kelly, C. N. P. (2009). "Saccharomyces boulardii Inhibits EGF Receptor Signaling and Intestinal Tumor Growth in Apcmin Mice". Gastroenterology 137 (3): 914–923. PMC 2777664. PMID 19482027. doi:10.1053/j.gastro.2009.05.050.
- Reid, G.; Dols, J.; Miller, W. (2009). "Targeting the vaginal microbiota with probiotics as a means to counteract infections". Current Opinion in Clinical Nutrition and Metabolic Care 12 (6): 583–587. PMID 19741517. doi:10.1097/MCO.0b013e328331b611.
- Osset, J.; Bartolomé, R. M.; García, E.; Andreu, A. N. (2001). "Assessment of the Capacity ofLactobacillusto Inhibit the Growth of Uropathogens and Block Their Adhesion to Vaginal Epithelial Cells". The Journal of Infectious Diseases 183 (3): 485–491. PMID 11133381. doi:10.1086/318070.
- Pascual, L. M.; Daniele, M. B.; Ruiz, F.; Giordano, W.; Pájaro, C.; Barberis, L. (2008). "Lactobacillus rhamnosus L60, a potential probiotic isolated from the human vagina". The Journal of general and applied microbiology 54 (3): 141–148. PMID 18654035.
- Inglin, Raffael C. (2015). "High-throughput screening assays for antibacterial and antifungal activities of Lactobacillus species". Journal of Microbiological Methods 114 (July 2015): 26-29. doi:10.1016/j.mimet.2015.04.011.
- Twetman, S; Stecksén-Blicks, C (2008). "Probiotics and oral health effects in children". International Journal of Paediatric Dentistry 18 (1): 3–10. PMID 18086020. doi:10.1111/j.1365-263X.2007.00885.x.
- Meurman, J. H.; Stamatova, I (2007). "Probiotics: Contributions to oral health". Oral Diseases 13 (5): 443–51. PMID 17714346. doi:10.1111/j.1601-0825.2007.01386.x.
- Prakash, S. et al. “The Gut Microbiota and Human Health with an Emphasis on the Use of Microencapsulated Bacterial Cells”, Journal of Biomedicine and Biotechnology (2011),
- 16x16px Data related to Lactobacillus at Wikispecies
- List of species of the genus Lactobacillus
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