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Open Access Articles- Top Results for Lanosterol

Lanosterol

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Lanosterol
250px
Ball-and-stick model of lanosterol
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IUPAC name
lanosta-8,24-dien-3-ol
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79-63-0 7pxY
ChEBI CHEBI:16521 7pxN
ChEMBL ChEMBL225111 7pxN
ChemSpider 216175 7pxN
Jmol-3D images Image
MeSH Lanosterol
PubChem Template:Chembox PubChem/format
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C30H50O
Molar mass 426.71 g/mol
Melting point Script error: No such module "convert".
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Lanosterol is a tetracyclic triterpenoid, which is the compound from which all steroids are derived.

Role in creation of steroids

Elaboration of lanosterol under enzyme catalysis leads to the core structure of steroids. 14-Demethylation of lanosterol by CYP51 eventually yields cholesterol.

File:Sterol synthesis.svg
Simplified version of the lanosterol synthesis pathway with the intermediates isopentenyl pyrophosphate (IPP), dimethylallyl pyrophosphate (DMAPP), geranyl pyrophosphate (GPP), and squalene shown. Some intermediates are omitted.

Biosynthesis

Description Illustration Enzyme
Two molecules of farnesyl pyrophosphate condense with reduction by NADPH to form squalene 400px squalene synthase
Squalene is oxidized to 2,3-oxidosqualene (squalene epoxide) 400px squalene monooxygenase
2,3-Oxidosqualene is converted to a protosterol cation and finally to lanosterol 400px lanosterol synthase
(step 2) 400px (step 2)

See also

References

External links